Fig. 4

Pathological load of cortical Aβ, pTau, axonal damage and microvascular deterioration in AD phenotypes and controls. Boxplots of immunoreactivity of histological markers Amyloid beta (A) pTau (D) NfL (G) and COLIV (J) as area% load in selected brain regions in control and AD phenotype groups (behavioral, dysexecutive, logopenic and visuospatial). Radar plots showing the distribution of pathology load among control, typical AD, atypical AD (B, E, H, K), and distinct subtype groups (C, F, I, L). * = p ≤ 0.05, ** = p ≤ 0.01, *** = p ≤ 0.001. Hip = hippocampus, ParaHip = parahippocampal gyrus, GFM = middle frontal gyrus, GTM = middle temporal gyrus, GPS = superior parietal gyrus, Precun = precuneus, PCC = posterior cingulate cortex, OC = occipital cortex