Fig. 6

Regional Volume-Pathology associations for AD clinical phenotypes. Standardized betas of volume-pathology associations are presented in a heatmap to provide a better overview of all regional associations. For each significant association, scatterplots with regression lines are plotted. By definition, control cases have little-to-no pTau load in the selected regions therefore control volume-pathology associations for pTau are not included and are designated by the – sign. Hip = hippocampus, ParaHip = parahippocampal gyrus, GFM = middle frontal gyrus, GTM = middle temporal gyrus, GPS = superior parietal gyrus, Precun = precuneus, PCC = posterior cingulate cortex, OC = occipital cortex