Table 2 Cumulative incidence and hazard ratio of Alzheimer’s disease between groups
Simple competing risk model | Multiple competing risk model** | Propensity score- matched model | ||||||
|---|---|---|---|---|---|---|---|---|
Year | NUC Treatment group | Cumulative Incidence (95% CI) | HR (95% CI) | P-value | HR (95% CI) | P-value | HR (95% CI) | P-value |
2 | NUC (-) | 0.0002 (0.0002–0.0003) | 1.00 | 1.00 | 1.00 | |||
NUC (+) | 0.0001 (0 − 0.0004) | 0.46 (0.11–1.91) | 0.286 | 0.51 (0.12–2.05) | 0.339 | 0.40 (0.08–2.06) | 0.273 | |
3 | NUC (-) | 0.0004 (0.0003–0.0005) | 1.00 | 1.00 | 1.00 | |||
NUC (+) | 0.0002 (0–0.0005) | 0.44 (0.14–1.38) | 0.156 | 0.55 (0.18–1.69) | 0.294 | 0.43 (0.11–1.66) | 0.220 | |
4 | NUC (-) | 0.0006 (0.0005–0.0007) | 1.00 | 1.00 | 1.00 | |||
NUC (+) | 0.0002 (0.0001–0.0005) | 0.37 (0.14-1.00) | 0.051 | 0.51 (0.19–1.39) | 0.187 | 0.36 (0.12–1.14) | 0.083 | |
5 | NUC (-) | 0.0009 (0.0008–0.0010) | 1.00 | 1.00 | 1.00 | |||
NUC (+) | 0.0003 (0.0001–0.0006) | 0.31 (0.13–0.75) | 0.009 | 0.41 (0.17-1.00) | 0.049 | 0.33 (0.12–0.92) | 0.033 | |
6 | NUC (-) | 0.0012 (0.0011–0.0013) | 1.00 | 1.00 | 1.00 | |||
NUC (+) | 0.0005 (0.0002–0.0009) | 0.41 (0.21–0.80) | 0.009 | 0.55 (0.28–1.07) | 0.079 | 0.41 (0.19–0.89) | 0.024 | |
7 | NUC (-) | 0.0015 (0.0013–0.0017) | 1.00 | 1.00 | 1.00 | |||
NUC (+) | 0.0006 (0.0003–0.0011) | 0.40 (0.22–0.73) | 0.003 | 0.54 (0.29–0.99) | 0.045 | 0.38 (0.19–0.76) | 0.006 | |