Table 3 Independent samples t-tests examining differences in demographic factors, blood pressure indicators and plasma markers by biological sex
| Â | Males M(SD) | Females M(SD) | p-value |
|---|---|---|---|
Age (years) | 73.7(8.1) | 72.8(8.2) | 0.57 |
Education (years) | 17.5(2.1) | 17.5(1.9) | 0.97 |
Systolic blood pressure (BP, mmHg) | 136.0(14.3) | 129.9(17.5) | 0.053 |
Diastolic BP (mmHg) | 76.4(9.7) | 72.0(9.0) | 0.02 |
Pulse pressure (systolic BP-diastolic BP, mmHg) | 59.7(12.9) | 57.9(15.1) | 0.52 |
Amyloid beta 42/40 ratio (Aβ42/40) | 0.06(0.001) | 0.06(0.001) | 0.46 |
Glial fibrillary acidic protein (GFAP) | 149.3(66.0) | 183.1(99.7) | 0.04 |
Neurofilament light chain (NfL) | 29.2(14.2) | 29.9(15.1) | 0.81 |
Tau phosphorylated at threonine-181 (pTau181) | 4.7(2.5) | 3.2(1.5) | 0.0005 |