Skip to main content

Table 4 Comparison of the original and revised definition of MetS in the association with incident dementia in the Whitehall II and UK biobank cohorts

From: Optimizing midlife metabolic syndrome thresholds for dementia: a prospective study of two UK population-based cohorts

 

N dementia cases/Total

 

HR (95% CI)

p-value for HR comparisonc

C-statistic

(95% CI)

p-value for

C-statistic comparisond

Reference group

High-risk group

 

Model 1a

Model 2b

WHITEHALL II

    

Median follow-up 22.6 (IQR 19.1, 27.7) years

    

Metabolic syndrome (≥ 3 cardiometabolic components)e

        

 Original MetS definition

435/4,669

87/946

 

1.16 (0.92, 1.47)

1.15 (0.91, 1.44)

0.19

0.573 (0.545, 0.601)

0.69

 Revised MetS definitionf

422/4,999

100/1,038

 

1.26 (1.01, 1.57)

1.22 (0.98, 1.52)

0.574 (0.546, 0.602)

Increment of 1 cardiometabolic componentg

        

 Original MetS definition

522/6,137

 

1.07 (0.99, 1.15)

1.06 (0.98, 1.14)

< 0.01

0.574 (0.547, 0.602)

0.64

 Revised MetS definitionf

522/6,137

 

1.12 (1.04, 1.20)

1.11 (1.03, 1.19)

0.576 (0.548, 0.604)

UK BIOBANK

       

Median follow-up 13.8 (IQR 13.0, 14.4) years

       

Metabolic syndrome (≥ 3 cardiometabolic components)e

       

 Original MetS definition

170/103,165

248/68,721

 

1.38 (1.13, 1.68)

1.31 (1.08, 1.60)

0.01

0.630 (0.601, 0.659)

0.04

 Revised MetS definitionh

165/103,647

253/68,239

 

1.56 (1.28, 1.90)

1.49 (1.22, 1.83)

0.637 (0.608, 0.666)

Increment of 1 cardiometabolic componentg

       

 Original MetS definition

418/171,886

 

1.18 (1.10, 1.27)

1.16 (1.08, 1.25)

< 0.01

0.637 (0.608, 0.665)

0.21

 Revised MetS definitionh

418/171,886

 

1.23 (1.14, 1.33)

1.21 (1.12, 1.30)

0.640 (0.611, 0.668)

  1. MetS: metabolic syndrome; HR: hazard ratio; CI: confidence interval; IQR: interquartile range; HDL-C: high density lipoprotein-cholesterol;
  2. a Model 1: analysis adjusted for age (as time-scale), sex, education, marital status (living alone in UK Biobank), and birth cohort (5-year groups; only in Whitehall II)
  3. b Model 2: model 1 and adjustment for health-related behaviors (smoking, alcohol consumption, consumption of fruits and vegetables, and physical activity)
  4. c Using original threshold as the reference
  5. d Using original threshold as the reference
  6. e The reference group for each definition was composed of participants classified as without MetS
  7. f Contal& O’Quigley method’s thresholds for triglycerides (≥ 2.13 mmol/L) and fasting glucose (≥ 5.20 mmol/L)
  8. g The reference group for each definition was composed of participants without any MetS component
  9. h Contal& O’Quigley method’s thresholds for triglycerides (≥ 2.13 mmol/L) and glycated haemoglobin (≥ 29.8 mmol/mol)
Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193