Table 2 Top 10 most significant CpGs associated with the Resilience Index (RI) in the analysis of blood samples from the HBI cohort. The robust linear model included methylation M value as the outcome, RI in z-scores as the main independent variable, and covariate variables age, sex, diagnosis (MCI, CN), APOE4 allele count, and the first two PCs of the estimated immune cell-type proportions. Estimates describe changes in DNA methylation M values associated with a one standard deviation increase in RI after adjusting for covariate variables. A positive (or negative) value of the Estimate indicates hypermethylation (or hypomethylation) of the CpG associated with increased values in RI. In GREAT annotations, gene promoter regions are highlighted in red text, and the numbers in parentheses indicate distance from the TSS. Abbreviations RI Resilience Index, MCI mild cognitive impairment, CN cognitive normal, PC principal component, TSS transcription start site 

From: DNA methylation signature of a lifestyle-based resilience index for cognitive health