Fig. 3
Prefrontal tDCS restores cognitive and non-cognitive functions in 7-month-old Tg2576 mice. a The graph shows the total time spent exploring objects (novel and/or familiar) during the NOR test, conducted 24 h after the training phase, by 7-month-old WT and Tg2576 mice receiving tDCS or Sham stimulation (WT Sham: n = 8; WT tDCS: n = 6; Tg Sham: n = 10; Tg tDCS: n = 9; WT Sham *p = 0.0391 with Wilcoxon matched-pairs test; WT tDCS *p = 0.0285, Tg tDCS *p = 0.0425 both with Paired t-test). b The plot represents the total locomotor activity, quantified as the distance travelled during the exploration of a novel environment in the open field test, by 7-month-old WT and Tg2576 mice following Sham or tDCS treatment (WT Sham: n = 10; WT tDCS: n = 12; Tg Sham: n = 13; Tg tDCS: n = 13; WT Sham–Tg Sham *p = 0.0246; WT tDCS–Tg Sham *p = 0.0129; Tg Sham–Tg tDCS *p = 0.0444, all with 2-tailed Welch’s t-test). c The two box-and-whisker plots show antidepressant-like responses in the TST, quantified by the time spent in passive (immobility, left) and active (right) behaviours, reflecting coping strategies in 7-month-old WT Sham (n = 8), WT tDCS (n = 9), Tg Sham (n = 10) and Tg tDCS (n = 8) mice (2-way ANOVA: interaction F1,31 = 3.968, p = 0.0552. Tg Sham–Tg tDCS *p = 0.0303 unpaired t-test, for both active and passive behaviours). [Figure created using BioRender.com]