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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Repetitive prefrontal tDCS activates VTA dopaminergic neurons, resulting in attenuation of Alzheimer’s Disease-like deficits in Tg2576 mice

Fig. 5

Prefrontal tDCS reduces Aβ plaque burden in 12-month-old Tg2576 mice. a Representative confocal images showing intracellular Aβ levels (6E10, green) in the hippocampal CA1 region of 7-month-old Tg Sham and Tg tDCS mice (scale bar: 50 μm). Plot displays intracellular Aβ levels, measured as mean fluorescence intensity for 6E10 (n = 4 mice/group). b Representative confocal images of extracellular Aβ plaques (6E10, green) in the hippocampus of 12-month-old Tg2576 mice receiving Sham or tDCS stimulation (scale bar: 200 μm). Nuclei are counterstained with DAPI. The insets (scale bar: 50 μm) show individual plaques. The plots on the right report the number of Aβ plaque (left) and plaque area (right) (Plaque number: Tg Sham: n = 5 mice; Tg tDCS: n = 4 mice; *p = 0.0453 unpaired t-test; Plaque area: Tg Sham: n = 30 plaques/5 mice; Tg tDCS: n = 22 plaques/4 mice)

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Alzheimer's Research & Therapy

ISSN: 1758-9193