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Table 3 Hazard ratios (HRs) and 95% confidence intervals (CIs) for incident young-onset all-cause dementia across subgroups by waist circumference categories

From: Abdominal obesity and the risk of young-onset dementia in women: a nationwide cohort study

Subgroup

All-cause dementia

< 75

< 85

< 95

≥ 95

p for interaction

Age

40–49

1 (Ref.)

1.21 (1.04‒1.42)

1.56 (1.26‒1.94)

1.77 (1.17‒2.68)

0.142

50–60

1 (Ref.)

1.10 (1.02‒1.19)

1.19 (1.08‒1.31)

1.50 (1.28‒1.75)

 

Household income, low

No

1 (Ref.)

1.13 (1.04‒1.22)

1.24 (1.13‒1.37)

1.53 (1.30‒1.81)

0.995

Yes

1 (Ref.)

1.14 (0.98‒1.32)

1.24 (1.03‒1.50)

1.60 (1.18‒2.18)

 

Smoking

No

1 (Ref.)

1.14 (1.06‒1.23)

1.24 (1.14‒1.36)

1.57 (1.35‒1.83)

0.454

Yes

1 (Ref.)

0.91 (0.65‒1.27)

1.23 (0.84‒1.81)

1.15 (0.61‒2.18)

 

Alcohol consumption

No

1 (Ref.)

1.12 (1.04‒1.22)

1.24 (1.13‒1.37)

1.57 (1.34‒1.84)

0.935

Yes

1 (Ref.)

1.15 (0.97‒1.35)

1.24 (1.01‒1.52)

1.41 (0.98‒2.04)

 

Regular exercise

No

1 (Ref.)

1.14 (1.05‒1.23)

1.26 (1.15‒1.39)

1.54 (1.31‒1.80)

0.805

Yes

1 (Ref.)

1.08 (0.92‒1.28)

1.15 (0.93‒1.42)

1.63 (1.14‒2.34)

 

Diabetes mellitus

No

1 (Ref.)

1.14 (1.05‒1.22)

1.27 (1.15‒1.39)

1.63 (1.37‒1.92)

0.462

Yes

1 (Ref.)

1.02 (0.80‒1.30)

1.06 (0.82‒1.37)

1.25 (0.90‒1.73)

 

Hypertension

No

1 (Ref.)

1.15 (1.06‒1.25)

1.30 (1.17‒1.46)

1.47 (1.16‒1.87)

0.424

Yes

1 (Ref.)

1.06 (0.92‒1.21)

1.14 (0.98‒1.32)

1.51 (1.24‒1.85)

 

Dyslipidemia

No

1 (Ref.)

1.14 (1.05‒1.23)

1.27 (1.14‒1.41)

1.54 (1.26‒1.87)

0.922

Yes

1 (Ref.)

1.11 (0.96‒1.27)

1.19 (1.02‒1.39)

1.54 (1.23‒1.93)

 

Depression

No

1 (Ref.)

1.12 (1.04‒1.21)

1.17 (1.07‒1.29)

1.55 (1.33‒1.82)

0.005

Yes

1 (Ref.)

1.20 (0.97‒1.48)

1.75 (1.39‒2.20)

1.56 (1.05‒2.32)

 

Atrial fibrillation

No

1 (Ref.)

1.13 (1.06‒1.22)

1.25 (1.14‒1.36)

1.55 (1.34‒1.79)

0.616

Yes

1 (Ref.)

0.66 (0.30‒1.48)

1.03 (0.42‒2.48)

1.31 (0.37‒4.70)

 

Stroke

No

1 (Ref.)

1.14 (1.06‒1.22)

1.25 (1.15‒1.37)

1.61 (1.38‒1.87)

0.225

Yes

1 (Ref.)

0.94 (0.66‒1.36)

1.01 (0.68‒1.51)

0.77 (0.39‒1.53)

 
  1. aHRs (95% CIs) were calculated using a multivariable Cox proportional hazard regression analysis after adjusting for age, smoking status, alcohol consumption, regular exercise, low household income, diabetes mellitus, hypertension, dyslipidemia, depression, atrial fibrillation, stroke. HRs should be interpreted with caution due to potential instability of estimates
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Alzheimer's Research & Therapy

ISSN: 1758-9193