Fig. 1

Correlations between mGluR5 and synaptic density in the hippocampus and entorhinal cortex

[¹⁸F]FPEB (mGluR5) and [¹¹C]UCB-J (synaptic density) DVRs are plotted for participants with CN (blue, n = 12) and AD (red, n = 15). Univariate linear regression line of best fit, Pearson’s correlation coefficients (r) and the associated p values are shown for each group for (A) hippocampus and (B) entorhinal cortex. ^*p < 0.05. Abbreviations: AD = Alzheimer’s disease; CN = cognitively normal; DVR = Distribution volume ratio; mGluR5 = metabotropic glutamate receptor subtype 5; PVC = partial volume correction