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Table 1 Participant characteristics

From: Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

 

CN (Aβ −)

AD (Aβ +)

CN vs. AD

Sex (Male/Female)

6/6

7/8

χ2 (1) = 0.03, p = 0.863

Age (years)

70.1 ± 8.2

73.5 ± 5.9

t (25) = 1.27, p = 0.213

Education (years)

17.5 ± 2.1

16.8 ± 2.4

t (25) = 0.78, p = 0.441

CDR-global

0.0 ± 0.0

0.7 ± 0.2

U = 180, p < 0.001*

CDR-SB

0.0 ± 0.0

4.0 ± 2.2

U = 180, p < 0.001*

MMSE

29.1 ± 1.3

24.1 ± 3.9

t (17.7) = 4.59, p < 0.001*

LMII

14.0 ± 4.2

1.9 ± 2.6

t (25) = 9.16, p < 0.001*

APOE Genotype (ε2 ε3, ε3 ε3, ε3 ε4, ε4 ε4)

3, 7, 2, 0

0, 4, 8, 3

χ2 (3) = 0.61, p = 0.012*

Composite [18F]FPEB PET DVR

2.92 ± 0.44

2.81 ± 0.30

t (25) = 0.81, p = 0.424

Composite [11C]UCB-J PET DVR

1.70 ± 0.09

1.57 ± 0.07

t (25) = 3.95, p < 0.001*

Hippocampal [18F]FPEB PET DVR‍‍‍

2.33 ± 0.41

2.05 ± 0.31

t (25) = 2.02, p = 0.054

Hippocampal [11C]UCB-J PET DVR

1.09 ± 0.08

0.86 ± 0.10

t (25) = 6.18, p < 0.001*

  1. Mean ± standard deviation (continuous variables) or frequency (categorical variables) are shown for the group with normal cognition (n = 12) and Alzheimer’s disease (n = 15). Test statistics, degrees of freedom, and associated p values are reported for independent two-tailed t tests, Mann–Whitney U tests, or a χ2 test. *p < 0.05
  2. Abbreviations: Aβ amyloid β, AD Alzheimer’s disease, CDR-global clinical dementia rating global score, CDR-SB clinical dementia rating sum of boxes, CN cognitively normal, DVR Distribution volume ratio, LMII Logical Memory delayed recall, MMSE Mini-Mental Status Exam
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Alzheimer's Research & Therapy

ISSN: 1758-9193