Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

Salardini, Elaheh; O’Dell, Ryan S.; Tchorz, Em; Nabulsi, Nabeel B.; Huang, Yiyun; Carson, Richard E.; van Dyck, Christopher H.; Mecca, Adam P.

doi:10.1186/s13195-025-01739-1

Alzheimer's Research & Therapy

Table 2 Regional correlations between mGluR5 and synaptic density (no PVC)

From: Assessment of the relationship between synaptic density and metabotropic glutamate receptors in early Alzheimer’s disease: a multi-tracer PET study

	Left hemisphere						Right hemisphere
	AD		CN		Fisher’s r to z		AD		CN		Fisher’s r to z
Region	r	p	r	p	z	P	r	p	r	p	z	P
Frontal pole	0.30	0.283	0.09	0.771	0.48	0.631	0.40	0.143	−0.37	0.229	1.85	0.064
Superior frontal	−0.03	0.905	0.05	0.881	0.19	0.852	0.02	0.927	−0.02	0.939	0.11	0.909
Rostral middle frontal	0.13	0.650	−0.08	0.804	0.47	0.636	0.31	0.255	0.15	0.635	0.39	0.699
Caudal middle frontal	0.10	0.715	−0.17	0.590	0.63	0.528	0.39	0.152	0.08	0.813	0.76	0.449
Pars orbitalis	0.23	0.406	0.49	0.108	0.67	0.503	−0.10	0.720	0.19	0.554	0.66	0.506
Pars opercularis	0.21	0.453	0.36	0.244	0.38	0.702	0.52	0.048^*	0.44	0.149	0.22	0.827
Pars triangularis	0.24	0.397	0.33	0.287	0.24	0.807	0.37	0.171	0.47	0.126	0.26	0.796
Lateral orbitofrontal	0.40	0.136	0.12	0.714	0.70	0.483	0.29	0.290	0.46	0.136	0.43	0.663
Medial orbitofrontal	0.79	< 0.001^*	0.44	0.147	1.35	0.178	0.59	0.020^*	0.49	0.101	0.31	0.759
Temporal pole	0.93	< 0.001^*	0.36	0.247	2.99	0.003^*	0.91	< 0.001^*	0.53	0.076	2.12	0.034^*
Entorhinal	0.81	< 0.001^*	0.46	0.127	1.42	0.155	0.83	< 0.001^*	0.18	0.575	2.27	0.023^*
Parahippocampal	0.78	< 0.001^*	0.46	0.135	1.27	0.205	0.83	< 0.001^*	0.36	0.245	1.82	0.068
Hippocampus	0.81	< 0.001^*	0.68	0.014^*	0.64	0.523	0.80	< 0.001^*	0.80	0.002^*	0.05	0.960
Amygdala	0.70	0.003^*	0.49	0.108	0.77	0.440	0.90	< 0.001^*	0.56	0.056	1.87	0.061
Inferior temporal	0.71	0.003^*	0.38	0.225	1.13	0.259	0.74	0.002^*	0.34	0.278	1.35	0.177
Fusiform	0.62	0.014^*	0.26	0.420	1.04	0.298	0.79	< 0.001^*	0.29	0.355	1.75	0.081
Middle temporal	0.65	0.008^*	0.23	0.464	1.23	0.220	0.76	< 0.001^*	0.49	0.107	1.07	0.286
Bankssts	0.57	0.026^*	−0.43	0.162	2.51	0.012^*	0.60	0.017^*	0.46	0.131	0.45	0.652
Superior temporal	0.59	0.019^*	0.25	0.435	0.97	0.329	0.74	0.002^*	0.57	0.050	0.67	0.504
Transverse temporal	0.37	0.175	0.18	0.572	0.46	0.643	0.75	0.001^*	0.61	0.033^*	0.60	0.545
Supramarginal	0.50	0.058	0.16	0.626	0.88	0.377	0.55	0.032^*	0.31	0.318	0.68	0.497
Insula	0.46	0.087	0.21	0.511	0.63	0.526	0.70	0.003^*	0.61	0.035^*	0.38	0.704
Rostral anterior cingulate Cingulate	0.77	< 0.001^*	0.47	0.118	1.13	0.258	0.61	0.016^*	0.27	0.387	0.96	0.336
Caudal anterior cingulate	0.47	0.079	0.19	0.557	0.72	0.473	0.37	0.176	0.03	0.915	0.80	0.424
Posterior cingulate	0.34	0.219	−0.40	0.198	1.75	0.079	0.38	0.158	−0.24	0.460	1.46	0.144
Isthmus cingulate	0.45	0.093	0.42	0.175	0.08	0.934	0.75	0.001^*	0.24	0.453	1.68	0.092
Precuneus	0.27	0.335	−0.24	0.458	1.17	0.242	0.44	0.098	−0.02	0.949	1.12	0.260
Paracentral	0.07	0.811	0.002	0.993	0.15	0.883	0.28	0.315	−0.14	0.656	0.98	0.329
Postcentral	0.009	0.973	0.24	0.450	0.54	0.592	0.25	0.360	0.13	0.683	0.30	0.772
Precentral	0.06	0.837	−0.02	0.952	0.18	0.860	0.13	0.648	0.03	0.924	0.22	0.824
Superior parietal	0.20	0.468	−0.27	0.397	1.09	0.275	0.14	0.605	−0.10	0.763	0.55	0.580
Inferior parietal	0.27	0.325	−0.08	0.807	0.81	0.416	0.64	0.010^*	0.15	0.640	1.38	0.167
Lateral occipital	0.15	0.600	−0.29	0.351	1.03	0.304	0.35	0.204	−0.16	0.628	1.18	0.238
Cuneus	0.21	0.440	−0.36	0.246	1.36	0.174	0.34	0.208	−0.03	0.926	0.88	0.376
Pericalcarine	0.20	0.477	0.38	0.225	0.44	0.656	0.44	0.102	0.21	0.512	0.58	0.559
Lingual	0.28	0.302	−0.02	0.944	0.72	0.472	0.54	0.037^*	0.23	0.477	0.85	0.395
Thalamus	0.26	0.344	0.25	0.431	0.03	0.978	0.35	0.203	0.63	0.026^*	0.87	0.381
Caudate	0.79	< 0.001^*	0.72	0.008^*	0.35	0.722	0.76	< 0.001^*	0.70	0.012^*	0.33	0.738
Putamen	0.24	0.397	0.21	0.504	0.05	0.958	0.12	0.656	0.18	0.563	0.14	0.888
Pallidum	0.18	0.526	0.58	0.049^*	1.08	0.279	0.08	0.765	0.37	0.232	0.70	0.485
Accumbens area	0.33	0.230	0.07	0.820	0.61	0.542	0.41	0.126	0.57	0.052	0.48	0.632
Ventral Diencephalon	0.24	0.395	0.009	0.976	0.52	0.599	0.50	0.054	0.09	0.768	1.05	0.295

Pearson’s r and associated p value is reported for the correlation between [¹⁸F]FPEB (mGluR5) and [¹¹C]UCB-J PET (synaptic density) DVR in each brain region. Fisher r-to-z transformation was used to compare correlation coefficients of CN and AD groups. The data were from 12 CN participants 15 participants with AD. ^* p < 0.05. Abbreviations: AD Alzheimer’s disease, CN cognitively normal, DVR Distribution volume ratio, PVC Partial volume correction

Back to article page

ISSN: 1758-9193

Contact us

General enquiries: journalsubmissions@springernature.com