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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine

Fig. 5

m6A mRNA Epitranscriptomic Microarray analysis. A-C: Hierarchical clustering heatmap of EMCI/Control (A), LMCI/Control (B), and LMCI/EMCI (C). Each row represented one mRNA, and each column represented one sample. D-F: Volcano plot analysis of EMCI/Control (D), LMCI/Control (E), and LMCI/EMCI (F). Red boxes represented upregulated transcripts (≥ 1.5-fold change, P < 0.05), and blue boxes represented downregulated transcripts (≤ 0.7-fold change, P < 0.05). G-I: Four-quadrant diagram of changed transcripts in both m6A methylation and mRNA expression of EMCI/Control (G), LMCI/Control (H), and LMCI/EMCI (I). Red dots: hypermethylated-upregulated mRNAs; green dots: hypermethylated-downregulated mRNAs; purple dots: hypomethylated-upregulated mRNAs; blue dots: hypomethylated-downregulated mRNAs. P < 0.05. J-L: The interaction between m6A methylation and mRNA expression. (J) Hypermethylation-upregulation, (K) Hypomethylation-upregulation, (L) Hypomethylation-downregulation

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Alzheimer's Research & Therapy

ISSN: 1758-9193