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Table 6 Associations of gut metabolites with risks of EMCI and LMCI

From: Linking oxysterols and different stages of mild cognitive impairment: insights from gut metabolites and N6-methyladenosine

 

EMCI/CON

LMCI/CON

LMCI/EMCI

Gut metabolites

OR

P

OR

P

OR

P

3-Epipapyriferic acid

0.510

(0.255, 1.018)

0.056

1.681

(0.864, 3.271)

0.126

3.024

(1.495, 6.117)

0.002*

Fasciculic acid B

0.404

(0.195, 0.837)

0.015*

1.455

(0.648, 3.266)

0.363

4.721

(1.863, 11.965)

0.001*

Phorbol myristate

0.306

(0.114, 0.817)

0.018*

1.815

(0.688, 4.785)

0.228

5.341

(1.844, 15.470)

0.002*

Biochanin a 8-c-glucoside

1.329

(0.578, 3.053)

0.503

7.640

(1.792, 32.573)

0.006*

3.472

(1.165, 10.347)

0.025*

Procyanidin dimer B7

0.630

(0.268, 1.477)

0.288

2.877

(1.117, 7.409)

0.029*

5.739

(1.843, 17.867)

0.003*

Thromboxane B2

0.544

(0.257, 1.152)

0.112

2.523

(0.934, 6.816)

0.068

5.487

(1.738, 17.326)

0.004*

2,3-dinor, 6-keto-pgf1alpha

0.371

(0.144, 0.955)

0.040*

4.057

(0.896, 18.369)

0.069

7.101

(1.662, 30.337)

0.008*

Thymol-beta-d-glucoside

0.528

(0.224, 1.243)

0.144

2.967

(1.052, 8.363)

0.040*

5.458

(1.890, 15.759)

0.002*

Cyclo(Leu-Phe)

0.692

(0.439, 1.090)

0.112

1.613

(0.955, 2.723)

0.074

2.281

(1.339, 3.886)

0.002*

N2-Fructopyranosylarginine

0.453

(0.170, 1.211)

0.115

4.138

(1.147, 14.934)

0.030*

8.819

(2.133, 36.459)

0.003*

  1. Abbreviations: EMCI, early mild cognitive impairment; LMCI, late mild cognitive impairment; OR, odds ratio. ∗P < 0.05
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Alzheimer's Research & Therapy

ISSN: 1758-9193