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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Early presentation of spastic paraparesis in individuals carrying PSEN1 mutations: a clinical and genetic analysis

Fig. 2

Brain MRI images of patients with PSEN1-related spastic paraparesis. (A-C) The three patients carrying a heterozygous PSEN1 p.F386S variant from Pedigree Q397. Patient IV-3 showed generalized brain atrophy (A) whereas the other two patients showed no remarkable atrophic change (B and C). (D) The patient R963 carries a heterozygous PSEN1 p.P284S variant. The MRI images showed no remarkable brain atrophy

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Alzheimer's Research & Therapy

ISSN: 1758-9193