Table 1 Characteristics of biomarker study participants at baseline
Initial Plasma | Clinical 48-week Change | MRI 48-week Change | |
|---|---|---|---|
na | 319 | 264 | 230 |
Demographics | |||
Age: mean (SD) | 71.52 (8.03) | 71.53 (8.08) | 71.47 (8.02) |
Sex: N (%) male | 132 (41.4) | 113 (42.8) | 100 (43.5) |
APOE ε4 carrier: N (%) positive | 213 (66.8) | 181 (68.6) | 163 (70.9) |
Education: mean (SD) | 15.28 (3.07) | 15.18 (3.01) | 14.98 (2.85) |
Race: N (%) | |||
Asian | 4 (1.25) | 4 (1.52) | 4 (1.74) |
Black or African American | 9 (2.82) | 9 (3.41) | 6 (2.61) |
Native Hawaiian or Other Pacific Islander | 1 (0.31) | 0 (0.00) | 0 (0.00) |
White | 305 (95.6) | 251 (95.1) | 220 (95.7) |
Ethnicity: N (%) | |||
Hispanic or Latino | 9 (2.82) | 6 (2.27) | 4 (1.74) |
Not Hispanic or Latino | 307 (96.2) | 256 (97.0) | 224 (97.4) |
Not Reported | 3 (0.94) | 2 (0.76) | 2 (0.87) |
Clinical Measurements (measured at baseline) | |||
MMSE: mean (SD) | 19.35 (3.84) | 19.23 (3.86) | 19.46 (3.83) |
MoCA: mean (SD) | 12.59 (4.78) | 12.57 (4.68) | 12.86 (4.71) |
ADAS-Cog11: mean (SD) | 25.97 (8.10) | 26.07 (8.19) | 25.69 (8.22) |
CDR-SB: mean (SD) | 6.46 (2.47) | 6.45 (2.47) | 6.40 (2.51) |
Plasma Biomarker Measurements (measured at baseline) | |||
Aβ42/40: mean (SD) | 0.05 (0.01) | 0.05 (0.01) | 0.05 (0.01) |
GFAP, pg/mL: mean (SD) | 399.9 (173.6) | 390.0 (168.2) | 390.7 (167.6) |
NfL, pg/mL: mean (SD) | 29.05 (11.45) | 28.72 (11.38) | 28.36 (10.80) |
P-tau181, pg/mL: mean (SD) | 4.14 (1.59) | 4.04 (1.54) | 4.04 (1.54) |
T-tau, pg/mL: mean (SD) | 2.36 (1.25) | 2.34 (1.24) | 2.33 (1.26) |