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Fig. 2 | Alzheimer's Research & Therapy

Fig. 2

From: Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer’s disease

Fig. 2

MC intrinsic properties of Tg2576 MCs suggest altered excitability. A. The timeline of the recordings for the analysis of MC intrinsic properties. 1. Measurements from responses to hyperpolarizing current steps. 2–3. Measurements of APs. B. Representative traces of membrane potential responses from WT (black) and Tg2576 MCs (red) to a positive (60 and 70 pA, respectively) and consecutive negative current steps from − 10 to -30 pA using a 10 pA increment. The AP phase plot is shown in the inset. C. (1) RMPs were significantly more depolarized in Tg2576 than WT MCs. (2) The time constant was significantly shorter in Tg2576 MCs. 3–4. Rheobase (3) and the time to peak of the AP (4) were significantly reduced in Tg2576 MCs. The data in 1–4 suggest enhanced excitability of Tg2576 MCs. 5–6. AP peak amplitude (5) and maximum rising slope (6) were significantly reduced in Tg2576 MCs. While the data in 1–4 suggest increased excitability, data in 5–6 would potentially decrease excitability

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Alzheimer's Research & Therapy

ISSN: 1758-9193