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Fig. 3 | Alzheimer's Research & Therapy

Fig. 3

From: Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer’s disease

Fig. 3

Firing behavior of WT and Tg2576 MCs. (A) Representative traces show the response of WT and Tg2576 MCs to current steps of low and high amplitude eliciting few and larger numbers of APs, respectively. (B) Quantification of the mean firing frequency in response to current steps showed Tg2576 MCs generated a higher mean firing frequency than WT MCs (asterisk, p < 0.05). (C) (1) A plot of MC RMP vs. rheobase of the same cell for WT and Tg2576 MCs. Means and SEMs are indicated by the blue and red bars. There were no significant differences. (2) A plot of MC RMP vs. the AP threshold of the same cell shows no significant difference between genotypes. The data in C1 and C2 suggest that the relatively depolarized RMPs of Tg2576 mice did not affect rheobase or AP threshold significantly

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Alzheimer's Research & Therapy

ISSN: 1758-9193