Skip to main content
Fig. 4 | Alzheimer's Research & Therapy

Fig. 4

From: Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer’s disease

Fig. 4

Tg2576 MC E/I balance suggests increased excitability. (A) Increased E/I ratio in Tg2576 MCs compared to WT MCs. The ratio of sEPSCs (AMPA-sEPSCs) to sIPSCs was increased for Tg2576 MCs based on mean frequency (1) but not mean amplitude (2). (B) 1–2. Charge transfer of excitatory currents (AMPA-sEPSCs) based on the sum of event areas (1) or all values (2). 3–4. Charge transfer of inhibitory currents (sIPSCs) was significantly different between genotypes. 5. The E/I ratio for charge transfer based on mean values showed Tg2576 MCs had a slightly increased charge transfer ratio but it was not significant

Back to article page

Alzheimer's Research & Therapy

ISSN: 1758-9193