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Fig. 5 | Alzheimer's Research & Therapy

Fig. 5

From: Increased excitability of dentate gyrus mossy cells occurs early in life in the Tg2576 model of Alzheimer’s disease

Fig. 5

Increased spontaneous excitatory and inhibitory events in Tg2576 GCs. (A) The timeline of the slice preparation and the electrophysiological recordings for spontaneous synaptic activity in GCs, which was analogous to MCs. A biocytin-filled GC (blue) is shown. (B) GC EPSPs. (1) Representative traces of sEPSPs from WT (black) and Tg2576 mice (red). (2) Tg2576 GCs did not show a significant change in mean frequency nor amplitudes. (3) The frequency and cumulative distributions showed significant differences. C. GC AMPA-EPSCs. (1) Representative traces of AMPA-sEPSCs from WT (black) and Tg2576 mice (red). (2) Tg2576 GCs had a higher frequency of sEPSCs but not amplitudes. (3) The frequency and cumulative distributions showed significant differences. D. GC sIPSCs. Representative traces of GC sIPSCs showed increased frequency but not amplitude of Tg2576 GCs. 3. Frequency distributions of sIPSCs amplitudes showed more small events in Tg2576 mice. (4) Cumulative distributions were significantly different

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Alzheimer's Research & Therapy

ISSN: 1758-9193