Fig. 8

MC axons increase in Tg2576 mice. A. A diagram shows the plane that was used to generate horizontal sections selected from different parts of the septotemporal axis. B. The subregions of the DG are illustrated. Immunofluorescence for calretinin, a marker of MCs, (red) and DAPI (blue), a marker of cell bodies, are shown. C. Micrographs of horizontal sections from WT (1) and Tg2576 mice (2). The boxed areas are expanded below and illustrate the measurements of the calretinin-stained MC axon plexus (axon bundle, AB length) and the ML length (horizontal arrows). D. Tg2576 mice showed an increase in the calretinin-stained plexus (quantified as the % of the ML)