Fig. 2

Two MCI subtypes based on significantly altered covariance edges. (A) The brain map of the top 40 covariance edges significantly changed in at least 6% of patients. Red edges indicate Z-score > 0 and blue edges indicate Z-score < 0. The size of nodes is proportional to their degree. (B) The Z-score of the top 40 significantly altered covariance edges. (C) Degree of nodes involved in significantly altered covariance edges. (D) Group comparison results of the top 40 significantly altered covariance edges between two MCI subtypes using two-sample t-tests with age, gender, education, and ICV as covariates (subtype 1 vs. subtype 2). Asterisk (*) indicates structural covariance of significant differences between two subtypes (P < 0.05/40, Bonferroni correction). (E) The mean patterns of IDSCN for two MCI subtypes. The full names of the brain regions are shown in Supplementary Table 3. Abbreviations: CN = cognitively normal; ICV = intracranial volume; IDSCN = individual differential structural covariance network; MCI = mild cognitive impairment