Fig. 3

Comparisons of clinical characteristics between two MCI subtypes. (A) The pie chart on the left shows the number of subjects in subtype 1 and subtype 2. The two pie charts on the right show the number of clinical subgroups in subtype 1 and subtype 2, respectively. (B) Kaplan-Meier curves depict the probability of non-conversion to AD in subtype 1 (red) and subtype 2 (blue). Comparisons of demographics (C), cognitive characteristics (D), FDG values, and CSF biomarker levels (E) among the subtype 1, subtype 2, and CN. (F) Longitudinal changes in cognitive characteristics. Solid red (subtype 1) and blue (subtype 2) lines represent the fitted cognitive change as a function of follow-up time. * P < 0.05, ** P < 0.01, *** P < 0.001. Abbreviations: ADAS11 = Alzheimer’s Disease Assessment Scale Cognitive-11; ADAS13 = Alzheimer’s Disease Assessment Scale Cognitive-13; Aβ = amyloid-β; CDRSB = Clinical Dementia Rating Scale Sum of Boxes; CN = cognitively normal; CSF = cerebrospinal fluid; FDG = fludeoxyglucose; MCI_C/MCI_S/MCI_R = mild cognitive impairment converters/stable/reverters; MMSE = Mini-Mental State Examination; P-tau = phosphorylated tau; RAVLT = Rey Auditory Verbal Learning Test; Sub = subtype; y = year