Fig. 5

Analysis of covariance edges. (A) The correlation between the first canonical variable of the top 40 covariance edges and that of 10 clinical cognitive items. (B) The canonical loadings of these top 40 covariance edges. (C) The canonical loadings of 10 clinical cognitive items. (D) The word cloud represents keywords for 30 significant functional terms obtained by functional annotation of these top 40 covariance edges (P < 0.001, FDR correction). The larger text indicates a higher frequency of keywords. These 30 functional terms are shown in Supplementary Table 13. (E) The ARI values between clustering results based on different brain atlases and numbers of top edges. For example, AAL_5 represented clustering results using the AAL atlas and the top edges that were changed in at least 5% of MCI patients. The full names of the brain regions are shown in Supplementary Table 3. Abbreviations: AAL = Automated Anatomical Labeling; ADAS11 = Alzheimer’s Disease Assessment Scale Cognitive-11; ADAS13 = Alzheimer’s Disease Assessment Scale Cognitive-13; ARI = Adjusted Rand Index; BN = Brainnetome atlas; CDRSB = Clinical Dementia Rating Scale Sum of Boxes; FDR = false discovery rate; MMSE = Mini-Mental State Examination; RAVLT = Rey Auditory Verbal Learning Test