Table 1 Main demographic and clinical characteristics of participants

Demographics

Number of subjects

309

596

-

-

Age (years)

74.09 ± 5.91

74.19 ± 7.10

t = -0.23

0.820

Gender (males/females)

164/145

354/242

χ² = 3.32

0.068

Education (years)

16.60 ± 2.62

15.95 ± 2.82

t = 3.33

0.001

Clinical domains

MMSE

29.03 ± 1.19

27.45 ± 1.88

t = 15.44

< 0.001

ADAS11

5.73 ± 2.79

10.78 ± 4.63

t = -20.42

< 0.001

ADAS13

8.89 ± 4.25

17.39 ± 6.88

t = -22.84

< 0.001

RAVLT immediate

44.99 ± 9.85

32.86 ± 10.07

t = 17.31

< 0.001

RAVLT learning

6.05 ± 2.24

3.90 ± 2.58

t = 13.03

< 0.001

CDRSB

0.00 ± 0.00

1.58 ± 0.89

t = -43.33

< 0.001

Memory

0.98 ± 0.47

0.14 ± 0.53

t = 24.47

< 0.001

Executive

0.76 ± 0.49

0.28 ± 0.55

t = 13.52

< 0.001

Language

0.83 ± 0.50

0.33 ± 0.49

t = 14.18

< 0.001

Visuospatial

0.59 ± 0.44

0.37 ± 0.55

t = 6.59

< 0.001

Metabolic biomarkers

Number of subjects

161

424

-

-

FDG

1.29 ± 0.11

1.20 ± 0.14

t = 7.77

< 0.001

CSF biomarkers

Number of subjects

154

391

-

-

Aβ

1256.09 ± 442.30

889.99 ± 415.14

t = 8.85

< 0.001

Tau

222.67 ± 82.15

302.68 ± 130.20

t = -8.57

< 0.001

P-tau

20.19 ± 7.93

29.64 ± 14.71

t = -9.64

< 0.001

Genotype

APOE ε4 (carriers/noncarriers) ^a

82/218

315/281

χ² = 52.66

< 0.001