Fig. 3
Dml for the holdout cohort and test cohort stratified by (a) CDR score (holdout; N = 160, CDR = 0; N = 384, CDR = 0.5; N = 215), (b) number of ApoE variants and (holdout; N = 160, ε3/ε3; N = 224, ε3/ε4; N = 252, ε4/ε4; N = 32), (c) MMSE score (holdout; N = 160, MMSE = 30; N = 119, MMSE = 28–29; N = 208, MMSE = 26–27; N = 88, MMSE = 21–25; N = 29). The statistical annotations were generated using Welch's t-tests between groups; ns: 0.05 < p < = 1, *: 0.01 < p < = 0.05, **: 0.001 < p < = 0.01, ***: 0.0001 < p < = 0.001, ****:p < = 0.0001. (d) Each dot represents one imaging derived brain phenotype and its proportion of outliers in the CDR = 0 subset (x-axis) and CDR = 0.5 subset (y-axis). The red-dotted line marks a linear regression between the two cohorts, where a gradient greater than 1 (dotted green line) indicates that the proportion of outliers for CDR = 0.5 is generally greater than the proportion of outliers for CDR = 0