Shared genetic architecture between leukocyte telomere length and Alzheimer’s disease

Table 1 Novel loci jointly associated with LTL and AD at conjfdr < 0.05

Locus	Lead SNP	CHR	Position	A1/A2	Nearest Gene	Functional Category	conjFDR	LTL			AD			Cor_Eff ^b
Locus	Lead SNP	CHR	Position	A1/A2	Nearest Gene	Functional Category	conjFDR	Z-score	P value	Novel ^a	Z-score	P value	Novel ^a	Cor_Eff ^b
1	rs17552904	7	50,318,308	T/G	AC020743.4	Intergenic	3.27E-02	3.705	2.11E-04	Yes	4.031	5.56E-05	Yes	+
2	rs12705073	7	99,774,122	C/T	GPC2	Intronic	1.09E-05	-5.575	2.47E-08	No	-5.840	5.22E-09	No	+
3	rs10437655	11	47,391,948	A/G	SPI1	Intronic	5.38E-04	-5.633	1.77E-08	No	4.865	1.14E-06	No	-
4	rs3098168	15	50,751,050	C/T	USP8	Intronic	8.69E-03	4.120	3.78E-05	Yes	-4.259	2.06E-05	Yes	-
5	rs4780338	16	11,031,156	T/C	DEXI	Intronic	2.15E-02	3.890	1.00E-04	Yes	4.038	5.39E-05	Yes	+
6	rs2680702	17	56,431,549	G/A	RNF43	ncRNA_intronic	3.39E-02	4.194	2.75E-05	Yes	-3.919	8.88E-05	Yes	-
7	rs1065853	19	45,413,233	T/G	APOE	Downstream	1.37E-04	-5.086	3.65E-07	Yes	-6.984	2.88E-12	No	+
8	rs1761452	19	54,815,366	T/C	AC008984.7	ncRNA_intronic	9.40E-03	-4.120	3.78E-05	Yes	-4.241	2.23E-05	No	+

Abbreviations: A1, allele 1 (effect allele); A2, allele 2 (noneffect allele); conjFDR, conjunctional false discovery rate; AD, Alzheimer’s disease; CHR, chromosome; Cor_Eff, concordancy of association directions between 2 traits; LTL, leukocyte telomere length; SNP, single nucleotide polymorphism
a Whether a locus was novel for 2 traits, according to the original GWAS or GWAS Catalog
b The directionality of allelic associations with both phenotypes in discovery data sets using z scores is shown here. + Indicates the same direction and -, the opposite direction

ISSN: 1758-9193